Home About us Editorial board Search Browse articles Submit article Instructions Contacts Login 
Users Online: 445
Home Print this page Email this page

 

ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 1  |  Page : 53

Studying the determinant factors leading to congenital heart disease in newborns


1 Department of Pediatrics, Pediatric Heart Disease Ward, Qom University of Medical Sciences, Qom, Iran
2 Department of Pediatrics, Medical Faculty, Qom University of Medical Science, Qom, Iran

Correspondence Address:
Dr. Mahsa Besharati
Department of Pediatrics, Medical Faculty, Qom University of Medical Science, Qom
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jehp.jehp_146_17

Rights and Permissions

Context: Congenital heart disease (CHD) is an important cause of death during the 1st year of life and includes a special group of cardiac diseases that exist from birth. These conditions arise due to the abnormal development of an embryo's normal structures. Aims: A case–control study was conducted to investigate the determinant factors leading to CHD. Materials and Methods: All newborns who have been diagnosed with CHD upon echocardiography in 2013 were considered as cases. The number of samples required was randomly selected from the newborns who lacked CHD on cardiography. The mothers of both groups were handed the questionnaires. Statistical Analysis Used: SPSS 23 was employed to analyze the data. Results: A statistically significant association was seen between CHD and a positive family history (FH) (P < 0.001), consanguinity (P < 0.001), maternal diabetes (P = 0.004), the use of antiepileptics during the first 45 days of gestation (P = 0.002), and the mother's education status (P > 0.001). No significant association was observed between CHD in the newborn and the age below 20 and above 35 years and (P = 0.11), maternal body mass index (BMI) (P = 0.44), smoking during the first 45 days of gestation (P = 0.017), and maternal rheumatologic diseases (P = 0.4). Conclusions: Newborns are at a greater risk of having CHD born from mothers with a FH of CHD, from consanguineous marriages, history of diabetes, antiepileptic use, and lack of folic acid use. However, no significant associations were found between newborn CHD and maternal age, BMI, or cigarette smoking.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed578    
    Printed25    
    Emailed0    
    PDF Downloaded114    
    Comments [Add]    
    Cited by others 2    

Recommend this journal