Home About us Editorial board Search Browse articles Submit article Instructions Contacts Login 
Users Online: 349
Home Print this page Email this page

 

ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 1  |  Page : 144

The effect of melatonin on the lipid levels in menopausal women: A double-blind, controlled, clinical trial


1 Research Center for Social Determinants of Health, Jahrom University of Medical Sciences, Jahrom, Iran
2 Department of Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran
3 Department of Physiology, Shiraz University of Medical Sciences, Shiraz, Iran
4 Department of Pharmacology, Shiraz University of Medical Sciences, Shiraz, Iran
5 Department of Pathology, Shiraz University of Medical Sciences, Shiraz, Iran

Correspondence Address:
Mrs. Khadijeh Abdali
Department of Midwifery, Shiraz University of Medical Sciences, Namazi Sq. Prophet, Fatemeh Zahra College of Nursing and Midwifery, Shiraz
Iran
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jehp.jehp_187_17

Rights and Permissions

BACKGROUND: Cardiovascular diseases are the major public health problem in many countries and are responsible for more than half of the deaths in above 50-year-old women. The most common curable risk factor of these disorders is hypoestrogenemia resulting from menopause. The present study aimed to investigate the effect of melatonin on plasma lipid levels in menopausal women. MATERIALS AND METHODS: The present double-blind, placebo-controlled, clinical trial was conducted in 2013–2014 on 240 menopausal women between 40 and 60 years old referring to the Gynecology and obstetrics clinics of Shiraz University of Medical Sciences who were randomly divided into two groups. The intervention group received 3 mg melatonin tablets and the control group received the placebo for 3 months. The data were gathered using the demographic information questionnaire and lipid profile test before and 3 months after the intervention. Then, the data were analyzed through the SPSS statistical software (version 16). The repeated measures analysis of variance, the least significant difference, the independent-sample t, the Chi-square, and Fisher's exact tests were done for data analysis. RESULTS: The two study groups were similar regarding the demographic and clinical variables at the beginning of the study. In the melatonin group, the amount of triglyceride increased from 140.34 ± 48.29 before the study to 151.24 ± 54.60 3 months after the intervention and no significant difference was observed between the two groups in this regard (confidence interval [CI] = 95%, P > 0.05). In addition, no significant difference was found between the two groups concerning low-density lipoprotein cholesterol level (CI = 95%, P = 0.125). CONCLUSION: Melatonin was not effective in reduction of lipid levels. However, further controlled studies are needed to be conducted on the issue.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed31    
    Printed0    
    Emailed0    
    PDF Downloaded5    
    Comments [Add]    

Recommend this journal